Evaluation of the effect of intrauterine clindamycin and gentamicin antibiotic injection after insemination to improve fertility in cows with a history of endometritis
Resumo
To evaluate the effect of intrauterine clindamycin and gentamicin antibiotic injection after insemination to improve fertility in cows with a history of endometritis, a total of 200 dairy cows from 4 farms were selected and used in two groups such as control and antibiotic groups. In the treatment group, a combination of clindamycin and gentamicin was injected once into the uterus 24 hours after artificial insemination. They were examined for pregnancy in a period of 120 days after insemination with antibiotics or, in case of infertility, for discharge, uterine consistency, and the effect of intrauterine antibiotic injection on subsequent inseminations. The degree of endometritis based on the severity of infection and milk production was assumed to be constant in both the Antibiotic and control groups. The fertility percentage and overall pregnancy rate, and the interval from insemination with antibiotics to pregnancy were compared in the two groups using the chi-square test and the T-test. According to the data, the overall pregnancy rate in the antibiotic-treated group 24 hours after insemination was increased and more than control group. Considering the first or numerous calving cows in both groups, the fertility rate in the multiparous calving cows with antibiotic injection was higher than the control group. Data revealed that fertility rates at the third and higher insemination periods were higher in both the antibiotic treatment and control groups. Additionally, the evaluation of the interval between days of parturition and insemination with antibiotics in the treatment and control groups showed that there were significant differences in the birth status of antibiotic-treated groups and better and natural birth status compared to the control. In conclusion, we may have demonstrated that intrauterine clindamycin and gentamicin antibiotic injection after insemination improved the fertility and overall pregnancy rate, and also natural birth status in cows with a history of endometritis.
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Referências
AMIRIDIS, G.S., FTHENAKIS, G.C., DAFOPOULOS, J., PAPANIKOLAOU, T., MAVROGIANNI, V.S. (2003). Use of cefquinome for prevention and treatment of bovine endometritis. J Vet Pharmacol Therap. 26. 387–390.
ARTHUR, G.H., NOAKES, D.E., PEARSON, H. (1989). Veterinary Reproduction and Obstetrics, sixth ed. Bailliere Tindall, England. 340.
BARRAGRY, T.B. (1994). Veterinary drug therapy. Philadelphia: Lea and Febiger, 224-6, 251-262.
BATEMAN, K.C., KEEL, G.P., WALTER, J.S., JOHNSON, W.H. (2002). The effect of treatment of clinical endometritis on reproductive performance in dairy cows. J. Dairy Sci. 85. 2237–2249.
BONDURANT, R.H. (1999). Inflammation in the bovine female reproductive tract. J Anim Sci. 77 (2). 101-110.
BRETZLAFF, K.N. (1986). Factors of importance for the disposition of antibiotics in the female genital tract. In: Morrow, D.A. (Ed.), Current Therapy of Theriogenology. W.B. Saunders Co., Philadelphia, PA, pp. 34–47.
DOHMEN M.J.W., LOHUIS J.A.C.M., HUSZENICZA G.Y., NAGY P., GACS M., 1995, The relationship between bacteriological and clinical findings in cows with subacute or chronic endometritis, Theriogenology, Vol.43, 1379-1388.
FARO, S. (2005). Postpartum endometritis. Clin Perinatol. 32(3). 803–814.
HAJURKA, J., NAGY, J., POPELKA, P., ROZEMSKA, H., SOKOL, J., CABADAJ, R., HURA, V. (2003). Tetracycline concentration in blood and milk of cows following intrauterine treatment of acute or sub-acute/chronic endometritis. Bull Vet Inst Pulawy. 47(2). 435-447.
HAIMERL, P., ARLT, S., BORCHARDT. S., HEUWIESER, W. (2016). Antibiotic treatment of metritis in dairy cows. A meta-analysis. J Dairy Sci. 2017.100(5).3783–3795.
KHAN, A. KHAN, M.Z. (1989). Efficacy of different antibiotics in the treatment of endometritis in Pakistan buffaloes. J Islamic Acad Sci. 2(2).153.
KIM, I.H. AND KANG, H.C. (2003). Risk factors for postpartum endometritis and the effect of endometritis on reproductive performance in dairy cows in Korea. J Reprod Dev. 49 (6).485–490.
KHAIR A, ASADUZZAMAN M, SULTANA Z, TALUKDER AK, DAS ZC, ALAM MGS, SHAMSUDDIN M. (2018). Economic benefit in repeat breeder cows using intrauterine infusion of penicillin and estrus synchronization followed by timed artificial insemination. J Adv Vet Anim Res. 30;5(4):454-458.
Livingston JC, Llata E, Rinehart E, Leidwanger C, Mabie B, Haddad B, Sibai B. (2003). Gentamicin and clindamycin therapy in postpartum endometritis: the efficacy of daily dosing versus dosing every 8 hours. Am J Obstet Gynecol 188 (1):149-152.
MOHAMMED, S.N. (2024). Bacteriological findings, vaginal discharges, and endometrial cytology for endometritis detection in postpartum buffaloes. DJVS.2 (3): 31-49.
MOSAFERI S, DAVATGAR BADIE A, AND NIKNIAZ, H. (2013). Effect of intrauterine antibiotic injection 24 hours after insemination on conception rate in cows with endometritis. Annals of Biological Research 4 (5): 312-315.
OXENDER D.W., SEGUIN B.E. (1976). Bovine intrauterine Therapy, Timothy R. Ayliffe, JAVMA, Vol. 168, No. .3, 217-219.
RICHVOL.N, G.F. (1993). Metritis and endometritis. In: Howard JL. Current veterinary therapy 3: food animal practice. Philadelphia: W.B. Saunders Company 770–772.
SINHA, R. N., SINHA, A. K., ALAM M., AND SINGH B. (1994) Concentration of gentamicin in endometrial tissue after muscular and uterine routes of administration in cows. Indian J. Anim. Reprod, 15: 29-31.
SINGH, G. (I994). Efficacy of gentamicin sulphate treatment of repeat breeding cows. Indian J. Anim. Reprod, 15: 162.
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