Effective Phyto Therapeutic Agents for Parkinson's disease: Promising Medicinal Plants for Parkinson's Disease Management in Animal and Cellular Models
Resumo
Parkinson's disease is a progressive neurodegenerative disorder predominantly affecting the elderly, characterized by symptoms such as muscle rigidity, tremors, and impaired motor function. Despite the absence of a definitive cure, various pharmacological agents, notably levodopa, are employed to manage symptoms and enhance quality of life. Within the realm of traditional Iranian medicine, which boasts a rich history spanning thousands of years, Parkinson's disease is often referred to as tremors. Scholars in this field have documented the underlying causes, clinical manifestations, and natural remedies associated with tremors in numerous texts. This review aims to elucidate the pathophysiological mechanisms of Parkinson's disease while exploring herbal therapies documented in traditional Iranian practices. Notable medicinal plants, including Ferulago angulate, Curcuma longa, Foeniculum vulgare, Panax ginseng, Thymus vulgaris, Crocus sativus, Berberis vulgaris, Cinnamomum verum, Cuminum cyminum, and Gerbera jamesonii, have demonstrated efficacy in combating the disorder. These plants exhibit mechanisms that may counteract neuronal degeneration and reduce movement-related disabilities, thereby offering a multi-faceted strategy for managing Parkinson's disease. Future research should focus on elucidating the specific biochemical pathways involved and conducting clinical trials to validate the efficacy and safety of these herbal interventions. By bridging the gap between traditional knowledge and modern pharmacotherapy, we may enhance therapeutic outcomes for individuals living with Parkinson's disease.
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Referências
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