Linfoma alimentar linfocítico felino - Uma revisão de literatura.

Marina Moller Nogueira, Marília Martins Melo

Resumo


O linfoma ou linfossarcoma é considerado o tumor maligno mais comum dos felinos, representando um terço de todas as neoplasias malignas diagnosticadas na espécie. O linfoma alimentar é a forma anatômica mais comum nessa espécie, seguido pelo mediastinal e o multicêntrico. O linfoma alimentar pode ser dividido, histopatologicamente, entre pequenas células, linfocítico, de baixo grau, bem diferenciado, ou de grandes células, linfoblástico, de alto grau. O linfoma de grandes grânulos é um subtipo caracterizado pela presença de linfócitos T natural killer, que têm presença característica de grânulos intracitoplasmáticos. Os tipos de linfomas alimentares são neoplasias distintas, com apresentações clínicas, terapias e prognósticos diferentes. Além disso, é difícil diferenciá-los de outras doenças não neoplásicas, como a doença inflamatória intestinal e outras inflamações crônicas do trato gastrointestinal felino.



Palavras-chave


Linfossarcoma, neoplasia, gato.

Referências


AMORIM, R.L. Imunoistoquímica em oncologia veterinária. Em: DALECK, C.R.; DE NARDI, A.B; RODASKI, S. Oncologia em cães e gatos. São Paulo: Roca, 2008. P. 136-148.

BALAN, M; HOPE, A; CASSIDY, J; MCCULLOUGH, M; O´BRIEN, P.J.O. Marked paraneoplastic basophilia accompanying eosinophilia in a cat with alimentary T-cell lymphoma. Journal of Feline Medicine and Surgery Open Reports, p. 1-6, 2017.

BARRS, V; BEATTY, J. Feline alimentary lymphoma: 1. Classification, risks factors, clinical signs and non-invasive diagnostics. Journal of Feline Medicine and Surgery, v.14, n.3, p.182-190, 2012.

CONCEIÇÃO, A.S.M.M..; NETO, J.L.S.; FREIRE, R.F.; COSTA, P.P.C. Infecção pós-cirúrgica em felino-Relato de caso. Revista Brasileira de Higiene e Sanidade Animal (v.11, n.2) p. 198 –215, abr -jun (2017). http://dx.doi.org/10.5935/1981-2965.20170022

ETTINGER, S.N. Principles of treatment for feline lymphoma. Clinical Techniques in Small Animal Practice, v.18, n.2, 98-102, 2003.

EVANS, S.E; BONCZYNKSI, J.J; BROUSSARD, J.D; HAN, E; BAER, K.E. Comparison of endoscopic and full thickness biopsy specimens for diagnosis of inflammatory bowel disease and alimentary tract lymphoma in cats. Journal of the American Veterinary Medical Association, v.229, n.9, p.1447-1450, 2006.

FONDACARO, J.V; RICHTER, K.P; CARPENTER, J.L; HART, J.R; HILL, S.L; FETTMAN, M.J. Feline gastrointestinal lymphoma: 67 cases (1988-1996). European Journal of Comparative Gastroenterology, vol. 4, n.2, p. 5-11, 1999.

GIEGER, T. Alimentary lymphoma in cats and dogs. Veterinary Clinics of North America- Small Animal Practice, v.41, p. 419-432, 2011.

GONDIM, A.L.C.L; ARAUJO, A.K.L. Síndrome da fragilidade cutânea em felinos – Revisão de literatura. Revista Brasileira de Higiene e Sanidade Animal (v.14, n. 2) p. 281 –288 Abr –jun (2020). http://dx.doi.org/10.5935/1981-2965.20200025.

KISELOW, M.A; RASSNICK, K.M; MCDONOUGH, S.P, GOLDSTEIN, R.E; SIMPSON, K.W; WEINKLE, T.K; ERB, H.N. Outcome of cats with low-grade lymphocytic lymphoma: 41 cases (1995- 2005). Journal of the American Veterinary Medical Association, v.232, n.3, p. 405-410, 2008.

KIUPEL, M.; SMEDLEY, R.C; PFENT, C; IE, Y.; WISE, A.G; DE VAUL, J.M; MAES, R.K. Diagnostic algorithm to differentiate lymphoma from inflammation in feline small intestinal biopsy samples. Veterinary Pathology, v.48, n.1, p.212-222, 2011.

KLEINSCHMIDT, S; HARDER, J; NOLTE, I; MARSILIO, S; HEWICHER-TRATWEIN, M. Chronic inflammatory and non-inflammatory diseases of the gastrointestinal tract in cats: diagnostic advantages of full-thickness intestinal and extraintestinal biopsies. Journal of Feline Medicine and Surgery, v.12, n.2, p. 97-103, 2010.

LALOR, S; SCHWARTZ; A.M; TITMARSH, H; REED, N; TASKER, S; BOLAND, L; BERRY, J; GUNN-MOORE, D; MELLANBY, R.J. Cats with inflammatory bowel disease and intestinal small cell lymphoma have low serum concentrations of 25-hydroxyvitamin D. Journal of Veterinary Internal Medicine, v.28, n.2, p. 351-355, 2014.

LINGARD, A.E; BRISCOE, K; BEATTY, J.A; MOORE, A.S; CROWLEY, A.M; KROCKENBERGER, M; CHURCHER, R.K; CANFIELD, P.J; BARRS, V.R. Low-grade alimentary lymphoma: clinicopathological findings and response to treatment in 17 cases. Journal of Feline Medicine and Surgery, v.11, n.8, p. 692-700, 2009.

LOUWERENS, M; LONDON, C.A; PEDERSEN, N.C; LYONS, L.A. Feline Lymphoma in the Post-Feline Leukemia Virus Era. Journal of Veterinary Internal Medicine, v.19, n.3, p. 329-335, 2005.

MAcVEAN, D.W; MONLUX, A.W; ANDERSON, P.S. Jr; SILBERG, S.L; ROSZEl, J.F. Frequency of canine and feline tumors in a defined population. Veterinary Pathology, v.15, n.6, p. 700-715, 1978.

METZGER, Fred. How do you treat cats with intestinal lymphoma? Source of Veterinary Medicine, 2010.

MOORE, P.F; RODRIGUEZ-BERTOS, A; KASs, P.H. Feline gastrointestinal lymphoma: mucosal architecture, immunophenotype, and molecular clonality. Veterinary Pathology, v.49, n.4, p. 658-668, 2012.

MOORE, P.F; WOO, J.C; VERNAU, W; KOSTEN, S; GRAHAM, P.S. Characterization of feline T cell receptor gamma (TCRG) variable region genes for the molecular diagnosis of feline intestinal T cell lymphoma. Veterinary Immunology and Immunopathology, v. 106, n.3-4, p. 167-178, 2005.

NORSWORTHY, G. The Feline Patient. 5ed. Wiley Blackwell, p. 381-384 e 935-939, 2018.

POPE, K.V; TUN, A.E; MCNEILL, C.J; BROWN, D.C; KRICK, E.L. Outcome and toxicity assessment of feline small cell lymphoma: 56 cases (2000-2010). Veterinary Medicine and Science, v.1, n.2, p. 51-62, 2015.

RASSNICK, K.M; GIEGER, T.L; WILLIAMS, L.E; RUSLANDER, D.M; NORTHRUP, N.C; KRISTAL, O; MYERS, N.C; MOORE, A.S. Phase I evaluation of CCNU (lomustine) in tumor-bearing cats. Journal of Veterinary Internal Medicine, v.14, n.3, p. 196-199, 2001.

RICHTER, K.P. Feline gastrointestinal lymphoma. Veterinary Clinics of North America- Small Animal Practice, v.33, n.5, p. 1083-1098, 2003.

RISSETTO, K; VILLAMIL, J.A; SELTING, K.A; TYLER, J; HENRY, C.J. Recent trends in feline intestinal neoplasia: an epidemiologic study of 1.129 cases in the veterinary medical database from 1964 to 2004. Journal of the American Animal Hospital Association, v.47, n.1, p.28-36, 2011.

ROCCABIANCA, P; VERNAU, W; CANIATTI, M. Feline Large Granular Lymphocyte (LGL) Lymphoma with secondary Leukemia: Primary Intestinal Origin with Predominance of a CD3/CD8 Phenotype. Veterinary Pathology, v.43, n.1, p 15-28, 2006.

SCHREURS, E; VERMOTE, K; BARBERET, V; DAMINET, S; RUDORF, H; SAUNDERS, J.H. Ultrasonographic anatomy of abdominal lymph nodes in the normal cat. Veterinary Radiology & Ultrasound, v.47, n.1, p. 68-72, 2008.

STEIN, T.J; PELLIN; MACKENZIE PELLIN, B.S; HOWARD, S; CHUN, R. Treatment of Feline Gastrointestinal Small-Cell Lymphoma with Chlorambucil and Glucocorticoids. Journal of American Animal Hospital Association, v. 46, n. 6, p. 413-417, 2010.

WALY, N.E; GRUFFYDD-JONES, T.J; STOKES, C.R; DAY, M.J. Immunohistochemical diagnosis of alimentary lymphomas and severe intestinal inflammation in cats. Journal of Comparative Pathology, v. 133, n.4, p. 253-260, 2005.

WEBB, C.B. Feline laparoscopy for intestinal disease. Topics in Companion Animal Medicine, v. 23, p. 193-199, 2008.

WILLARD, M.D; MANSELL, J; FOSGATE, G.T; GUALTIERI, M; OLIVERO, D; LECOINDRE, P; TWEDT, D.C; COLLETT, M.G; DAY, M.J; HALL, E.J; JERGENS, A;E, SIMPSON, J.W; ELSE, R.W; WASHABAU, R.J. Effect of sample quality on the sensitivity of endoscopic biopsy for detecting gastric and duodenal lesions in dogs and cats. Journal of Veterinary Internal Medicine, v. 22, n.5, p. 1084-1089, 2008.

WILSON, H.M. Feline Alimentary Lymphoma: Demystifying the Enigma. Topics in companion animal medicine, v.23, n.4, p. 177-184, 2008.

WOLFESBERGER, B; FUCHS-BAUMGARTINGER, A; GREB, V; HAMMER, S.E; GRADNER, G; KNEODL, K; TICHY, A; REUTGEN, B.C; BEHAM-SCHMID, C. World Health Organization Classification of Lymphoid Tumors in Veterinary and Human Medicine: a Comparative Evaluation of Gastrointestinal Lymphomas in 61 cats. Journal of Comparative Pathology, v. 159, p. 1-10, 2018.

ZWINGENBERGER, A.L; MARKS, S.L; BAKER, T.W; MOORE, P.F. Ultrasonographic evaluation of the muscularis propria in cats with diffuse small intestinal lymphoma or inflammatory bowel disease. Journal of Veterinary Internal Medicine, v.24, n.2, p. 289-292, 2010.


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