Clinical, diagnostic and therapeutic approach of uveodermatologic syndrome in dogs: a review
Resumo
Canine uveodermatologic syndrome is an autoimmune disease that leads to the appearance of ophthalmic and dermatological signs, such as bilateral panuveitis, vitiligo, leukotrichia, alopecia and ulcerations. Due to the lack of information about the uveodermatologic syndrome, the objective of this work is to carry out a systematic review on the main aspects of the disease, alerting the veterinarian about its occurrence and the importance of its early diagnosis. Despite the rare reports within the small animal clinic, it is believed that dogs of the Akita breed may be predisposed by the number of reported cases, although there are several records with other breeds in the literature. The diagnosis is usually late, due to the fact that the eye lesions appear about a month before the cutaneous lesions, and involves the clinical reasoning of the veterinarian in association with the performance of histopathological exams of the lesions, which present inflammatory histio-lymphocitic infiltrates and disorganization of basal layer. The treatment is based on immunosuppression, with corticosteroids or other similar drugs, such as azathioprine and cyclosporine, continuing from the diagnosis until the disappearance of clinical signs and maintenance at low doses or in association with other immunomodulators.
Palavras-chave
Referências
ALSAEID, K.; MAJEED, H.A. Acute rheumatic fever: diagnosis and treatment. Pediatric Annals, v. 27, p.295-300, 1998.
ANGLES, J.M.; FAMULA, T.R.; PEDERSEN, N.C. Uveodermatologic (VKH-like) syndrome in American Akita dogs is associated with an increased frequency of DQA1*00201. Tissue Antigens, v. 66, n. 6, p. 656–665, 2005.
ASAKURA, S.; TAKAHARA, T.; ONISHI, T. Vogt–Koyanagi–Harada syndrome (uveitis diffusa acuta) in the Dog. Japanese Journal of Veterinary Medicine. v. 673, p. 449–455, 1977.
BLACKWOOD, S.E.; BARRIE, K.P.; PLUMMER, C.E.; TAYLOR, D.; NUNNERY, C. M.; SELTZER, J.D.; BEN-SHLOMO, G.; BROOKS, D.E. Uveodermatologic syndrome in a rat terrier. Journal of the American Animal Hospital Association, v. 47, n. 4, p. 56–63, 2011.
BOYD, S.R.; YOUNG, S.; LIGHTMAN, S. Immunopathology of the noninfectious posterior and intermediate uveitides. Survey of Ophthalmology, v. 46, n. 3, p. 209–233, 2001.
CARMOZINE, A.G.D.; JORGE, A.T.; HONSHO, C.S.; DIAS, F.G.G.; PEREIRA, L.F. Complicações oftalmológicas e dermatológicas de um cão com síndrome uveodermatológica: acompanhamento durante 9 meses. In: 17º Congresso Nacional de Iniciação Científica, 2017, São Paulo. Anais do Congresso Nacional de Iniciação Científica, São Paulo: SEMESP, São Paulo, 2017, p. 1-11.
CARTER, WALLACE J.; CRISPIN, SHEILA M.; GOULD, DAVID J.; DAY, MICHAEL J. An immunohistochemical study of uveodermatologic syndrome in two Japanese Akita dogs. Veterinary Ophtalmology, v. 8, n. 1, p. 17-24, 2005.
CAVALCANTI, A.O.C; SAMPAIO, G.R; MIAN, G.F. Síndrome Uveodermatológica: Revisao de Literatura: Uveodermatological syndrome: literature review. Revista de Educação Continuada - CRMV-SP: Revisão e Ensaio , Lavras, MG, v. 8, n. 2, p. 98-108, dez./2005
COTTELLL, B.D.; BARNETT, K.C. Harada’s disease in the Japanese Akita. Journal of Small Animal Practice, v. 28, n. 6, p. 517–521, 1987.
DE LUCIA, M.; MEZZALIRA, G.; BARDAGI, M.; FONDEVILA, D.M.; FABBRI, E.; FONDATI, A. A retrospective study comparing histopathological and immunopathological features of nasal planum dermatitis in 20 dogs with discoid lupus erythematosus or leishmaniosis. Veterinary Dermatology, v. 28, p. 200-e46, 2017.
FINAMOR, L.P.; JUNIOR, F.F.; MUCCIOLI C. Corticoterapia e uveítes. Arquivo Brasileiro de Oftalmologia, v.65, n.4, p.56-59, 2002.
FONSECA-ALVES, C.E.; NOBREGA, J.; LAUFER-AMORIM, R.; DE MOURA, V.M. B.D. Síndrome uveodermatológica canina: revisão de literatura. Revista de Ciência Veterinária e Saúde Pública, v. 1, n. 2, p. 125-134, 2014.
FORSTER, D.J.; CANO, M.R.; GREEN, R.L.; RAO, N.A. Echographic features of the Vogt- Koyanagi-Harada syndrome. Archives of Ophthalmology, v.108, n.10, 1990.
FORSYTHE, P.; PATERSON, S. Ciclosporin 10 years on: indications and efficacy. Veterinary Record, v. 174 (Suppl 2), p. 13-21, 2014.
GELATT, K.N.; OPHTHALMOLOGY, V.; EDITION, F. Canine Anterior Uvea: Diseases and Surgery. Essentials of Veterinary Ophthalmology, p. 276–300, 2014.
GODOY, C.A.L.; SAFATLE, A.M.V.; TEIXEIRA, A.L.; SOUZA, M.S.B.; BARROS, P.S.M. Uveodermatological syndrome in a cocker-poodle mixed breed dog. Archives of Veterinary Science, v.8, n.1, p.29-33, 2003.
HENDRIX, D.V.H. Canine Anterior Uvea: Diseases and Surgery. In: Essentials Veterinary Ophtalmology. 4 ed, Iowa: Black Publishing, 2007. Cap. 13, p. 275-300.
HERRERA; DUCHENE. Uveodermatological syndrome (Vogt-Koyanagi-Harada-like syndrome) with generalized depigmentation in a Dachshund. Veterinary Ophthalmology, v. 1, n. 1, p. 47–51, 1998.
HORIKAWA, T.; VAUGHAN, R.K.; SARGENT, S.J.; TOOPS, E.E.; LOCKE, E.P. Pathology in practice. Journal of the American Veterinary Medical Association, v. 253, n. 8, p. 997–1000, 2013.
KANG, M.H.; LIM, C.Y.; PARK, H.M. Uveodermatologic syndrome concurrent with keratoconjunctivitis sicca in a miniature poodle dog. Canadian Veterinary Journal, v. 55, n. 6, p. 585–588, 2014.
KIBAR, M.; ASLAN, O.; ARSLAN, K. Uveadermatological syndrome (Vogt-Koyanagi-Harada- like syndrome) with depigmentation in a Siberian Husky. Revue de Medecine Veterinaire, v. 165, n. 1–2, p. 57–60, 2014.
LAUS, J.L. SOUSA, M.G.; CABRAL, V.P.; MAMEDE, F.V.; TINUCCI-COSTA, M. Uveodermatologic syndrome in a Brazilian Fila dog. Veterinary Ophthalmology, v.7 n.3, p.193-196, 2004.
LIMA, E.R.; FUKAHORI, F.L.P.; DIAS, M.B.M.C.; SILVA, V.C.L.; REGO, M.S.A.; FERREIRA, M.A.Q.B. Síndrome úveodermatológica em um canino da raça akita – relato de caso. Acta Veterinaria Brasilica, Pernambuco, v. 7, p. 199-201, 2013.
MASSA, K.L.; GILGER, B.C.; MILLER, T.L.; DAVIDSON, M.G. Causes of uveitis in dogs: 102 cases (1989-2000). Veterinary Ophthalmology, v. 5, n. 2, p. 93–98, 2002.
MATIELLO, M.; CARVALHO, H.C.; ALVARENGA, H.; ALVARENGA, R.M.P. Síndrome de Vogt-Koyanagi-Harada. Caderno Brasileiro de Medicina, v.17, 2004.
MONDKAR, S.V.; BISWAS, J.; GANESH, S.K. Analysis of 87 cases with Vogt-Koyanagi-Harada disease. Japanese Journal of Ophthalmology, v.44, n.3, p.296-301, 2000.
O’KEEFE, G.A.D.; RAO, N.A. Vogt-Koyanagi-Harada disease. Survey of Ophthalmology, v. 62, n. 1, p. 1–25, 2017.
OLIVRY, T.; DEBOER, D.J.; FAVROT, C.; JACKSON, H.A.; MUELLER, R.S.; NUTTALL, T.; PRÉLAUD, P. Treatment of canine atopic dermatitis 2015 updated guidelines from the International Committee on Allergic Diseases of Animals (ICADA). BMC Veterinary Research, v. 11, n. 1, p. 1-15, 2015.
PYE, C.C. Uveodermatologic syndrome in an Akita. The Canadian Veterinary Journal, v.50, p. 861-864, 2009.
READ, R.W.; HOLLAND, G.N.; RAO, N.A.; TABBARA, K.F.; OHNO, S.; ARELLANES- GARCIA, J.; PIVETTI-PEZZI, P.; TESSLER, H.H.; USUI, M. Revised diagnostic criteria for Vogt-Koyanagi-Harada disease: report of an international committee on nomenclature. American Journal of Ophthalmology, v.131, n.5, p.647-652, 2001.
RHODEN, N.C. Pawprints in Japan Dogs in myth and History. 1th ed. California: Fire Lake Press, 2002, 131p.
SIGLE, K.J.; MCLELLAN, G.J.; HAYNES, J.S.; MYERS, R.K.; BETTS, D.M. Unilateral uveitis in a dog with uveodermatologic syndrome. Journal of the American Veterinary Medical Association, v.228, n. 4, p.543-548, 2006.
SUÁREZ, P.; HERNÁNDEZ, H. Síndrome uveodermatológico canino: reporte de caso. Journal of Agriculture and Animal Sciences, v.1, n. 1, p. 70–76, 2012.
THAM, H.L.; LINDER, K.E.; OLIVRY, T. Autoimmune diseases affecting skin melanocytes in dogs, cats and horses: vitiligo and the uveodermatological syndrome: a comprehensive review. BMC Veterinary Research, v. 15, n. 1, p. 1-17, 2019.
THOMAS, O.; CHAHORY, S. A case of uveodermatologic syndrome in a Bernese Mountain dog. Pratique médicale et chirurgicale de l’animal de compagnie, v.44, p.55-61, 2009.
TILLEY, L.P.; SMITH, F. W.K. Consulta Veterinária em 5 minutos espécies canina e felina. 2. ed. São Paulo: Manole, 2003. 1423 p.
TIZARD, I.R. Imunologia veterinária: introdução. 9. ed. São Paulo: Elsevier, 533p., 2014.
TRBOLOVA, A.; KOZAK, I.; SEVCIKOVA, Z.; BALICKY, I.; LEDECKY, V.; CAPIK, I. The occurrence of canine Vogt-Koyanagi-Harada as a syndrome in the Rottweiler. Folia Veterinaria, v. 47, n.4, p.193-196, 2003.
WHITLEY, N.T.; DAY, M.J. Immunomodulatory drugs and their application to the management of canine immune-mediated disease. Journal of Small Animal Practice, v. 52, n. 2, p. 70-85, 2011.
YAMAKI, K.; TAKIYAMA, N.; ITHO, N.; MIZUKI, N.; SEIYA, M.; SINSUKE, W.; HAYAKAWA, K.; KOTANI, T. Experimentally induced Vogt-Koyanagi-Harada disease in two Akita dogs. Experimental Eye Research, v. 80, n. 2, p. 273–280, 2005.
YAMAKI, K.; GOCHO, K.; HAYAKAWA, K.; KONDO, I.; SAKURAGI, S. Tyrosinase Family Proteins Are Antigens Specific to Vogt-Koyanagi-Harada Disease. The Journal of Immunology, v. 65, n. 12, p. 7323–7329, 2000.
ZARFOSS, M.K.; TUSLER, C.A.; KASS, P.H.; MONTGOMERY, K.; LIM, C.C.; MOWAT, F.; THOMASY, S.M. Clinical findings and outcomes for dogs with uveodermatologic syndrome. Journal of the American Veterinary Medical Association, v. 252, n. 10, p. 1263–1271, 2018.
Apontamentos
- Não há apontamentos.
Visitas