Medicinal Plants Used in Traditional Iranian Medicine for the Treatment of Gastric Ulcers: A Review of Animal and Clinical Studies
Resumo
Gastric ulcers are among the most prevalent gastrointestinal disorders, significantly affecting patients’ quality of life. Traditional Iranian Medicine (TIM), with its extensive use of medicinal plants, has historically played a vital role in the management of this condition. This review aims to examine the medicinal plants traditionally employed in Iran for the treatment of gastric ulcers. A comprehensive review of traditional Iranian medical texts and contemporary references was conducted. Sources included classical textbooks on traditional medicine and herbal therapy, as well as modern online databases. Reported traditional effects were subsequently compared with findings from preclinical and clinical studies. Numerous medicinal plants have been documented for their gastroprotective properties in TIM. Notable examples include Brassica oleracea L., Glycyrrhiza glabra L., Allium sativum L., Curcuma longa L., Pistacia lentiscus L. (resin), Capsicum annuum L., Aloe barbadensis Mill., Glycine max (L.) Merr., Vitis vinifera L., Camellia sinensis (L.) Kuntze, Mentha piperita L., Matricaria chamomilla L., Cicer arietinum L., Phaseolus vulgaris L., Lens culinaris Medik., Olea europaea L., Juglans regia L., Zingiber officinale Roscoe, Rosa damascena Mill., Rosmarinus officinalis L., Cuminum cyminum L., Cichorium intybus L., Cinnamomum verum J. Presl, Hypericum perforatum L., Ziziphora clinopodioides, Boswellia serrata Roxb., Morus alba L., Morus nigra L., Musa paradisiaca, Trigonella foenum-graecum L., Lactuca sativa L., Cocos nucifera L., Nigella sativa L., Chrysanthemum morifolium Ramat., Foeniculum vulgare Mill., Lavandula angustifolia Mill., Taraxacum officinale Weber, Salvia officinalis L., Scrophularia scorodonia, Plantago major L., Melissa officinalis, Citrus reticulata Blanco, and Achillea millefolium L. Medicinal plants used in traditional Iranian medicine demonstrate considerable potential in the prevention and treatment of gastric ulcers and may serve as valuable adjuncts in their clinical management.
Palavras-chave
Referências
ABBASI N, ASADZADEH R, SEYDI F, BAHMANI M. Ethnobotanical study of medicinal plants used for prostatitis in Dehloran county, Ilam province, western Iran. J Biochem Phytomed. 2024;3(2):20-25. doi:10.34172/jbp.2024.16.
ALI ZY, SALEM SA. Utilization of Morus nigra L. leaves in production of functional pudding for gastric ulcer. Environ Sci. 2018;13(3):337-67.
ALIZADEH M, HOSSEINIAZAR MM, ALAMI F, BARARNIA ADABI S. The effects of meal patterns on liver steatosis, fibrosis, and biochemical factors in patients with nonalcoholic fatty liver disease: a randomized controlled clinical trial. J Diabetes Metab Disord. 2024;23(1):987-997.
ALOMAIR MK, ALABDULADHEEM LS, ALMAJED MA, ALOBAID AA, ALKHALIFAH EA, YOUNIS NS, MOHAMED ME. Achillea millefolium essential oil mitigates peptic ulcer in rats through Nrf2/HO-1 pathway. Molecules. 2022;27(22):7908.
ALOTAIBI B, MOKHTAR FA, EL-MASRY TA, ELEKHNAWY E, MOSTAFA SA, ABDELKADER DH, ELHARTY ME, SALEH A, NEGM WA. Antimicrobial activity of Brassica rapa L. flowers extract on gastrointestinal tract infections and antiulcer potential against indomethacin-induced gastric ulcer in rats supported by metabolomics profiling. J Inflamm Res. 2021; 14:7411-30.
ALTEMEMY D. Blurred vision and medicinal plants. J Biochem Phytomed. 2024;3(1):3-4. doi:10.34172/jbp.2024.2.
AMIR N, DHAHERI AA, JABERI NA, MARZOUQI FA, BASTAKI SM. Comparative effect of garlic (Allium sativum), onion (Allium cepa), and black seed (Nigella sativa) on gastric acid secretion and gastric ulcer. Res Rep Med Chem. 2011; 3:3-9.
AN L, CAI W, MA Y, XIE Y, TIAN J, YU B, LI R. Protective effect of Citrus reticulata ‘Chachi’ leaves extracts on gastric ulcer and potential mechanism prediction based on network pharmacology. J Future Foods. 2025 Jul 9.
AZAR MRMH, AGHAZADEH H, MOHAMMED HN, et al. miR-193a-5p as a promising therapeutic candidate in colorectal cancer by reducing 5-FU and Oxaliplatin chemoresistance by targeting CXCR4. Int Immunopharmacol. 2021; 92:107345.
AZARY SY, KALBASI H, SETAYESH A, et al. Predictive value and main determinants of abnormal features of intraoperative cholangiography during cholecystectomy. Hepatobiliary Pancreat Dis Int. 2011;10(3):308-12.
BAHADEEN AREF B, FAKHRI S, MOROVATI MR, GHANBARI-MOVAHED M, MOHAMMADI NOORI E, MIRAGHAEI S, FARZAEI MH. Evaluating the protective effects of aqueous and hydroalcoholic extracts of Plantago major leaf in a rat model of ethanol-induced peptic ulcer. J Med Plants By-products. 2024;13(3):605-13.
BEHZADI F, ROOSTA Y. A review of medicinal plants effective against iron deficiency anaemia. Prog Biomed Pharm. 2025;7(2):10-15.
BENABDALLAH H, BENCHIKH F, MAMACHE W, AMIRA H, AMIRA S. Anti-ulcer, analgesic and antioxidant activities of aqueous extract of Foeniculum vulgare Mill seeds. Turk J Agric Food Sci Technol. 2022;10(10):2010-5.
BORATO DG, SCOPARO CT, MARIA-FERREIRA D, DA SILVA LM, DE SOUZA LM, IACOMINI M, WERNER MF, BAGGIO CH. Healing mechanisms of the hydroalcoholic extract and ethyl acetate fraction of green tea (Camellia sinensis (L.) Kuntze) on chronic gastric ulcers. Naunyn Schmiedebergs Arch Pharmacol. 2016;389(3):259-68.
BOUTEMINE IM, AMRI M, AMIR ZC, FITTING C, MECHERARA-IDJERI S, LAYAIDA K, SENNOUN N, BERKANE S, CAVAILLON JM, TOUIL-BOUKOFFA C. Gastro-protective, therapeutic and anti-inflammatory activities of Pistacia lentiscus L. fatty oil against ethanol-induced gastric ulcers in rats. Journal Ethnopharmacol. 2018; 224:273-82.
BUKAR MA, ISHAYA HB, DIBAL NI, ATTAH MO. Gastroprotective effect of Nigella sativa seed on ethanol-induced gastric ulcer in rats. Libyan J Med Sci. 2017;1(3):63-7.
CHANGAEE F. The role of native medicinal plants in supporting pregnancy health: a traditional medicine approach with their mechanisms of action. Prog Biomed Pharm. 2025;7(3):115-23. doi:10.61186/pbp.7.3.5
DAWOUD A. Acute dermal toxicity study of Aloe sinkatana. Prog Biomed Pharm. 2025;7(2):16-23. Available from: http://pbp.medilam.ac.ir/article-1-266-en.html.
ESWARAN MB, SURENDRAN S, VIJAYAKUMAR M, OJHA SK, RAWAT AK, RAO CV. Gastroprotective activity of Cinnamomum tamala leaves on experimental gastric ulcers in rats. J Ethnopharmacol. 2010;128(2):537-40.
GHASEMI A, VALIZADEH N, HASHEMI A. Evaluation of Helicobacter pylori IgG levels in type 2 diabetes mellitus patients. Clin Diabetol. 2020;9(3):179-83.
HAMED S, FAHMY NM, SINGAB ANB, MOHAMED RW. Anti-ulcer effects of cumin (Cuminum cyminum L.), thyme (Thymus vulgaris L.), and caraway (Carum carvi L.) essential oils on peptic ulcer and ulcerative colitis models in rats. 2022;389-400.
HUSSEIN MM. The effect of Hypericum perforatum extract on gastric ulcer development in rat models. Cihan Univ-Erbil Sci J. 2023;7(1):48-51.
JAFARI R, VAZIFEKHAH S. The most effective medicinal plants for toxoplasmosis-induced miscarriage and their mechanisms of action. Prog Biomed Pharm. 2025;7(3):139-47. doi:10.61186/pbp.7.3.14.
JALILZADEH-AMIN G, NAJARNEZHAD V, ANASSORI E, MOSTAFAVI M, KESHIPOUR H. Antiulcer properties of Glycyrrhiza glabra L. extract on experimental models of gastric ulcer in mice. Iran J Pharm Res. 2015;14(4):1163.
KARBALAEI DOUST S, NOURAFSHAN A. Antiulcerogenic effects of Matricaria chamomilla extract in experimental gastric ulcer in mice. 2009;198-203.
KAVITT RT, LIPOWSKA AM, ANYANE-YEBOA A, GRALNEK IM. Diagnosis and treatment of peptic ulcer disease. Am J Med. 2019;132(4):447-56.
KUMAR M, VERMA I, SINDHU RK, SRIVASTAVA R. Herbal bioactives for the treatment of gastrointestinal tract disorders. Herbal Drugs Manag Infect Dis. 2022:133-55.
LANAS A, CHAN FK. Peptic ulcer disease. Lancet. 2017;390(10094):613-24.
MALFERTHEINER P, CHAN FK, MCCOLL KE. Peptic ulcer disease. Lancet. 2009;374(9699):1449-61.
MEHRYAR HR, AZAR MRH, EBRAHIMI A, GARKAZ O. Examining the prevalence of gastrointestinal symptoms in patients with COVID-19 admitted to Imam Khomeini Hospital in Urmia in the first half of 2021. Tehran Univ Med J. 2024;82(4):339-45.
MEMARIANI Z, HAJIMAHMOODI M, MINAEE B, KHODAGHOLI F, YANS A, RAHIMI R, AMIN G, MOGHADDAM G, TOLIYAT T, SHARIFZADEH M. Protective effect of a polyherbal traditional formula consisting of Rosa damascena Mill., Glycyrrhiza glabra L. and Nardostachys jatamansi DC., against ethanol-induced gastric ulcer. Iran J Pharm Res. 2017;16(2):694.
MORADI M, HANACHI P, BAHRAMIKIA S, TAVAN M. Effect of green synthesized silver nanoparticles using the aqueous extract of Lavandula angustifolia Mill. against ethanol-induced gastric ulcers in rats. Biocatal Agric Biotechnol. 2025; 66:103584.
NIAZMAND S, DERAKHSHAN M, AHMADPOUR M, ERFANIAN KH, HOSSEINI KH. The inhibitory effect of Ziziphora clinopodioides Lam. on gastric acid output at basal, vagotomized and vagal stimulated conditions in rat. 2010;36-39.
OLIINYK P. Milk thistle oil and its beneficial effects on the liver and hepatic diseases. J Biochem Phytomed. 2024;3(1):1-2. doi:10.34172/jbp.2024.1.
PRUCKSUNAND C, INDRASUKHSRI B, LEETHOCHAWALIT M, HUNGSPREUGS K. Phase II clinical trial on effect of the long turmeric (Curcuma longa Linn.) on healing of peptic ulcer. Southeast Asian J Trop Med Public Health. 2001;32(1):208-15.
SABERI A, ABBASLOO E, SEPEHRI G, YAZDANPANAH M, MIRKAMANDARI E, SHEIBANI V, SAFI Z. The effects of methanolic extract of Melissa officinalis on experimental gastric ulcers in rats. Iran Red Crescent Med J. 2016;18(7): e24271.
SELMI S, ALIMI D, RTIBI K, JEDIDI S, GRAMI D, MARZOUKI L, HOSNI K, SEBAI H. Gastroprotective and antioxidant properties of Trigonella foenum graecum seeds aqueous extract (fenugreek) and omeprazole against ethanol-induced peptic ulcer. J Med Food. 2022;25(5):513-22.
SHOJASAADAT F, AYREMLOU P, HASHEMI A, MEHDIZADEH A, ZARRIN R. A randomized controlled trial comparing effects of a low-energy diet with n-3 polyunsaturated fatty acid supplementation in patients with non-alcoholic fatty liver disease. J Res Med Sci. 2019;24(1):21.
SINGH S, KHAJURIA A, TANEJA SC, KHAJURIA RK, SINGH J, JOHRI RK, QAZI GN. The gastric ulcer protective effect of boswellic acids, a leukotriene inhibitor from Boswellia serrata, in rats. Phytomedicine. 2008;15(6-7):408-15.
SUSSER M. Causes of peptic ulcer: a selective epidemiologic review. J Chronic Dis. 1967;20(6):435-56.
TAYEBI M, POURKHABBAZ H, RAZMJOUE D, POURKHABBAZ A, JAVANMARDI S. Investigating the impact of industrial wastewater from Khuzestan steel industries on heavy metal accumulation and morphological characteristics of the medicinal plant Dracocephalum moldavica L. J Biochem Phytomed. 2024;3(2):35-44. doi:10.34172/jbp.2024.18.
TODD J, WALL C. Jude's Seasonal Herbal Remedies: Recipes for Natural Healing. Llewellyn Worldwide; 2024 Jul 8.
USLU GA, Hamit US. Protective effect of Juglans regia L.(walnut) leaves extract against indomethacin induced gastric mucosal damage in rats. World J Adv Res Rev. 2022;13(3):264-70.
VAKIL N. Peptic ulcer disease: a review. JAMA. 2024; Dec 3.
YEOMANS ND. The ulcer sleuths: The search for the cause of peptic ulcers. J Gastroenterol Hepatol. 2011; 26:35-41.
ZHU K, YANG X, YANG C, YE X, ZHANG H. Gastro-protective actions of Aloe barbadensis Miller mitigate ethanol-induced gastric injury in rats. Trop J Pharm Res. 2020;19(12):2645-50.
Apontamentos
- Não há apontamentos.
Visitas


