Infecção por Leptospira spp. em Gatos (Felis silvestris catus). Uma Revisão

Taiã Mairon Peixoto Ribeiro, Helcileia Dias Santos, Sebastiana Adriana Pereira Sousa, Samara Rocha Galvão, Thássia Silva Reis, Valéria de Sá Jayme

Resumo


Felinos domésticos (Felis silvestris catus) podem ser infectados e parasitados por diferentes patógenos. Entre eles encontram-se o gênero bacteriano Leptospira spp. que podem infectar felinos e acarretar prejuízos a homeostase do animal e consequentemente sobre seu bem-estar. O gato infectado e com uma resposta imune comprometida poderá apresentar principalmente distúrbios renais, mas também sinais hepáticos entre outros. Para controlar, diagnosticar e tratar é necessário que o Médico Veterinário tenha conhecimentos em epidemiologia, diagnóstico e tratamento de leptospirose. O presente estudo objetiva discutir os aspectos epidemiológicos, clínicos e terapeuticos em relação à infecção por Leptospira spp.  e da leptospirose. Sabe-se que o gato não é mais considerado uma espécie refratária para leptospirose, portanto, sua epidemiologia e abordagem terapêutica necessita ser mais bem esclarecida.


Palavras-chave


Felino; Epidemiologia; Leptospirose; Roedores.

Referências


ADLER, B.; MOCTEZUMA, A.P. Leptospira and leptospirosis. Veterinary Microbiology, v.140, n.3-4, p.287-296, 2010.

ALVES, C.J.; VASCONCELLOS, S.A.; MORAIS, Z.M.; ANDRADE, J.S.L.; CLEMENTINO, I.J.; AZEVEDO, S.S.; SANTOS, F.A. Avaliação dos níveis de aglutininas antileptospiras em gatos no município de Patos - PB. Clínica Veterinária, Ano VIII, Edição 46, p.52–54, 2003.

ANDERSEN-RANBERG, E.U.; JENSEN, P.M.; PIPPER, C. Global patterns of leptospira prevalence in vertebrate reservoir hosts. Journal of Wildlife Diseases, v.52, p.3, p.1-10, 2016.

ASOH, T.; SAITO, M.; VILLANUEVA, S.Y.A.M.; KANEMARU, T.; GLORIANI, N.; YOSHIDA, S-I. Natural defense by saliva and mucosa against oral infection by Leptospira. Canadian Journal of Microbiology, v.60, n.6, p.383-389, 2014.

ARBOUR, J.; BLAIS, M.C.; CARIOTO, L.; SYLVESTRE, D. Clinical leptospirosis in three cats (2001–2009). Journal of the American Animal Hospital Association, v.48, n.4, p.256-260, 2012.

AZIZI, P.S.; MOMTAZ, H.; GOODARZI, A.M.; TAJBAKHSH, E. Pcr detection of leptospira in stray cats,probable reservoir. Bulletin de l'Académie vétérinaire de France,v.166,n.1, p.67-70, 2013.

AZÓCAR-AEDO, L.; MONTI, G.; JARA, R. Leptospira spp. in domestic cats from different environments: prevalence of antibodies and risk factors associated with the seropositivity. Animals, v.4, n.4, p.612-626, 2014a.

AZÓCAR-AEDO, L.; SMITS, H.L.; MONTI, G. Leptospirosis in dogs and cats: epidemiology, clinical disease, zoonotic implications and prevention. Archivos de medicina veterinária, v.46, n.3, p.337-348, 2014b.

BEAUDU-LANGE, C.; LANGE, E. Unusual clinical presentation of leptospirosis in a cat. Revue Vétérinaire Clinique, v.49, n.3, p.115-122, 2014.

BEDIR, O.; KILIC, A.; ATABEK, E.; KUSKUCU, A.M.; TURHAN, V.; BASUSTAOGLU, A.C. Simultaneous detection and differentiation of pathogenic and nonpathogenic Leptospira spp. by multiplex real-time PCR (TaqMan) assay. Polish Journal of Microbiology, v.59, p.167-173, 2010.

BENACER, D.; THONG, K.L.; OOI, P.T.; SOURIS, M.; LEWIS, J.W.; AHMED, A.A.; MOHD ZAIN, S.N. Serological and molecular identification of Leptospira spp. in swine and stray dogs from Malaysia. Tropical Biomedicine, v.34, n.1, p.89-97, 2017.

BETANCE, L.; PEDA, A.; CONAN, A.; RIBEIRO, J. Seroprevalence of leptospirosis in the feral cat population of St. Kitts. Journal of Animal Research and Technology, p.38-42, 2017. Disponível em: http://journals.atlas-publishing.org/index.php/JART/article/view/108.

BRASIL, A.W.L.; PARANTONI, R.N.; FEITOSA, T.F.; VILELA, V.L.R.; ALVES, C.J.; VASCONCELLOS, S.A.; DE AZEVEDO, S.S. Anti-Leptospira spp. antibodies in cats from the semiarid of the Paraíba State. Semina: Ciências Agrárias, v.35, n.6, p.3215-3220, 2014.

BRYSON, D.G.; ELLIS, W.A. Leptospirosis in a British domestic cat. Journal of Small Animal Practice, v.17, n.7, p.459-465, 1976.

CALDART, E.T.; CONSTANTINO, C.; PASQUALI, A.K.S.; BENITEZ, A.N.; HAMADA, F.N.; DIAS, R.C.F.; RORATO-NASCIMENTO, A.M.; MARANA, E.R.M.; NAVARRO, I.T.; MASCARENHAS, N.M.F.; FREITAS, J.C.; FREIRE, R.L. Zoonosis in dogs and cats attended by the birth control project: Toxoplasma gondii, Leishmania spp. and Leptospira spp., serodiagnosis and epidemiology. Semina: Ciências Agrárias, v.36, n.1, p.253-266, 2015.

CHAN, K.W.; HSU, Y.H.; HU, W.L.; PAN, M.J.; LAI, J.M.; HUANG, K.C.; CHOU, S.J. Serological and PCR detection of feline leptospira in southern Taiwan. Vector-Borne and Zoonotic Diseases, v.14, n.2, p. 118-123, 2014.

DESVARS, A.; NAZE, F.; BENNEVEAU, A.; CARDINALE, E.; MICHAULT, A. Endemicity of leptospirosis in domestic and wild animal species from Reunion Island (Indian Ocean). Epidemiology & Infection, v.141, n.6, p.1154-1165, 2013.

DIETRICH, M.; MÜHLDORFER, K.; TORTOSA, P.; MARKOTTER, W. Leptospira and Bats: Story of an Emerging Friendship. PLoS Pathogens, v.11, n.11, p.1-6, 2015a.

DIETRICH, M.; WILKINSON, D.A.; BENLALI, A.; LAGADEC, E.; RAMASINDRAZANA, B.; DELLAGI, K.; TORTOSA, P. Leptospira and paramyxovirus infection dynamics in a bat maternity enlightens pathogen maintenance in wildlife. Environmental Microbiology, v.17, n.11, p.4280-4289, 2015b.

DUPOUEY, J.; FAUCHER, B.; EDOUARD, S.; RICHET, H.; KODJO, A.; DRANCOURT, M.; DAVOUST, B. Human leptospirosis: an emerging risk in Europe? Comparative Immunology, Microbiology and Infectious Diseases, v.37, n.1, p. 77- 83, 2014.

DYBING, N.A.; JACOBSON, C.; IRWIN, P.; ALGAR, D.; ADAMS, P.J. Leptospira species in feral cats and black rats from Western Australia and Christmas Island. Vector-Borne And Zoonotic Diseases, v.17, n.5, p. 319-324, 2017.

ESTEVES, F.M.; GUERRA-NETO, G.; GIRIO, R.J.S.; SILVA-VERGARA, M.L.; CARVALHO, A.C.F.B. Detecção de anticorpos para Leptospira spp. em animais e funcionários do zoológico municipal de Uberaba, MG. Arquivos do Instituto Biológico, v.72, n.3, p.283-288, 2005.

EVANGELISTA, K.V.; COBURN, J. Leptospira as an emerging pathogen: a review of its biology, pathogenesis and host immune responses. Future Microbiology, v.5, n.9, p.1413-1425, 2010.

FAINE, S.; ADLER, B.; BOLIN, C.; PEROLAT, P. Leptospira and leptospirosis. 2nd Ed. Melbourne: MedSci, 2000. 272 p.

FENIMORE, A.; CARTER, K.; LUNN, K.F. Detection of leptospiruria in shelter cats in Colorado. Journal of Veterinary Internal Medicine, v.26, p.783, 2012.

FENNESTAD, K.L.; BORG-PETERSEN, C. Leptospirosis in danish wild mammals. Journal of Wildlife Diseases, v.8, n.343-351, 1972.

FOUTS, D.E.; MATTHIAS, M.A.; ADHIKARLA, H.; ADLER, B.; AMORIM-SANTOS, L.; BERG, D.E.; BULACH, D.; BUSCHIAZZO, A.; CHANG, Y.F.; GALLOWAY, R.L.; HAAKE, D.A.; HAFT, D.H.; HARTSKEERL, R.; KO, A.I.; LEVETT, P.N.; MATSUNAGA, J.; MECHALY, A.E.; MONK, J.M.; NASCIMENTO, A.L.; NELSON, K.E.; PALSSON, B.; PEACOCK, S.J.; PICARDEAU, M.; RICALDI, J.N.; THAIPANDUNGPANIT, J.; WUNDER, E.A. JR.; YANG, X.F.; ZHANG, J.J.; VINETZ, J.M. What Makes a Bacterial Species Pathogenic?: Comparative Genomic Analysis of the Genus Leptospira. PLoS Neglected Tropical Diseases, v.10, n.2, p.1-57, 2016.

FURTADO, M.M.; GENNARI, S.M.; IKUTA, C.Y.; JÁCOMO, A.T.A.; DE MORAIS, Z.M.; PENA, H.F.J.; PORFÍRIO, G.E.O.; SILVEIRA, L.; SOLLMANN, R.; SOUZA, G.O.; TÔRRES, G.M.; FERREIRA NETO, J.S. Serosurvey of Smooth Brucella, Leptospira spp. and Toxoplasma gondiiin Free-Ranging Jaguars (Panthera onca) and Domestic Animals from Brazil. PLoS One, v. 10, n.11, p. e0143816, 2015.

GREENE, C.E. Infectious diseases of the dog and cat. 4th ed. St. Louis: Elsevier/Saunders, 2012. 1354 p.

GUERRA-NETO, G.; GIRIO, R.J.S.; ANDRADE, T.M.; KOPROSKI, L.P.; MORAES, W.; SANTOS, L.C. Ocorrência de anticorpos contra Leptospira spp. em felídeos neotropicais pertencentes ao Criadouro de Animais Silvestres a Itaipu Binacional e ao zoológico municipal Bosque Guarani, Foz do Iguaçu, Estado do Paraná. ARS Veterinária, v.20, n.1, p.75-80, 2004.

HARTMANN, K.; EGBERINK, H.; PENNISI, M.G.; LLORET, A.; ADDIE, A.; BELÁK, S.; BOUCRAUT-BARALON, C.; FRYMUS, T.; GRUFFYDD-JONES, T.; HOSIE, M.J.; LUTZ, H.; MARSILIO, F.; MÖSTL, K.; RADFORD, A.D.; THIRY, E.; TRUYEN, E.U.; HORZINEK, M.C. Leptospira Species Infection In Cats Abcd guidelines on prevention and management. Journal of Feline Medicine and Surgery, v.15, p.576-581, 2013.

INGRAM, W.M.; GOODRICH, L.M.; ROBEY, E.A.; EISEN, M.B. Mice infected with low-virulence strains of toxoplasma gondii lose their innate aversion to cat urine, even after extensive parasite clearance. PLoS ONE, v.8, n.9, p.1-6, 2013.

JAMSHIDI, S.; AKAHAVIZADEGAN, M.; BOKAIE, S.; MAAZI, N.; GHORBAN-ALI, A. Serologic study of feline leptospirosis in Theran, Iran. Iran Journal of Microbiology, v.1, n.2, p.32-36, 2009.

JOBBINS, S.E.; ALEXANDER, K.A. Evidence of Leptospira sp. infection among a diversity of African wildlife species: beyond the usual suspects. Transactions of The Royal Society of Tropical Medicine and Hygiene, v.109, n.5, p. 349-351, 2015.

LANGSTON, C.E.; HEUTER, K.J. Leptospirosis. A re-emerging zoonotic disease. Veterinary Clinics of North America: Small Animal Practice, v.33, n.4, p. 791-807, 2003.

LAPOINTE, C.; PLAMONDON, I.; DUNN, M. Feline leptospirosis serosurvey from a Quebec referral hospital. The Canadian Veterinary Journal, v.54, n.5, p.497-499, 2013.

LEVETT, P.N. Leptospirosis. Clinical Microbiology Reviews, v.14, n. 2, p.296-326, 2001.

LILENBAUM, W.; MONTEIRO, R.V.; ALBUQUERQUE, C.E.; RISTOW, P.; FRAGUAS, S.; CARDOSO, V.S.; FEDULLO, L.P.L. Leptospiral antibodies in wild felines from Rio de Janeiro Zoo, Brazil. The Veterinary Journal, v. 168, n.2, p.191-193, 2004.

LILENBAUM, W.; NARDUCHE, L.; LOUREIRO, A.P.; PENNA, B.A. Letter to the Editor. Journal of Veterinary Internal Medicine, v.28, n.6, p.1633, 2014.

LINGAPPA, J.; KUFFNER, T.; TAPPERO, J.; WHITWORTH, W.; MIZE, A.; KAISER, R.; MCNICHOLL, J. HLA-DQ6 and ingestion of contaminated water: possible gene-environment interaction in an outbreak of leptospirosis. Genes and Immunity, v.5, p.197-202, 2004.

LOUREIRO, A.P.; MARTINS, G.; THOMÉ, S.; LILENBAUM, W. Laboratorial Diagnosis of Animal Leptospirosis. Revista Brasileira de Ciência Veterinária, v.20, n.3, p.119-126, 2013.

LUCHEIS, S.B.; FERREIRA JUNIOR, R.S. Ovine leptospirosis in Brazil. The Journal of Venomous Animals and Toxins including Tropical Diseases, v.17, n.4, p.394-405, 2011.

MARKOVICH, J.E.; ROSS, L.; MCCOBB, E. The Prevalence of leptospiral antibodies in free roaming cats in Worcester County, Massachusetts. Journal of Veterinary Internal Medicine, v.26, n.3, p.688-689, 2012.

MAYER, F.Q.; DOS REIS, E.M.; BEZERRA, A.V.A.; CERVA, C.; ROSA, J.; CIBULSKI, S.P.; LIMA, F.E.S.; PACHECO, S.M.; RODRIGUES, R.O. Pathogenic Leptospira spp. in bats: Molecular investigation in Southern Brazil. Comparative Immunology, Microbiology and Infectious Diseases, v.52, p.14-18, 2017.

MERIEN, F.; PORTNOI, D.; BOURHY, P.; CHARAVAY, F.; BERLIOZ-ARTHAUD, A.; BARANTON, G. A rapid and quantitative method for the detection of Leptospira species in human leptospirosis. FEMS Microbiology Letters, v.249, p.139-147, 2005.

MILLÁN, J.; CANDELA, M.G.; LÓPEZ-BAO, J.V.; PEREIRA, M.; JIMÉNEZ, M.A.; LEÓN-VIZCAÍNO, L. Leptospirosis in Wild and Domestic Carnivores in Natural Areas in Andalusia, Spain. Vector-Borne And Zoonotic Diseases, v.9, n.5, p.549-553, 2009.

MITTESTAINER, J.C.; MELCHERT, A.; RIBEIRO, J.F.A.; SARTORI, R.S.; JOAQUIM, S.F.; BRESCIANI, K.; LANGONI, H. Estudo soroepidemiológico da infecção por Leptospira spp. em gatos. Veterinária e Zootecnia, v.22, n.3, p.465-470, 2015.

MOREY, R.E.; GALLOWAY, R.L.; BRAGG, S.L.; STEIGERWALT, A.G.; MAYER, L.W.; LEVETT, P.N. Species-Specific Identification of Leptospiraceae by 16S rRNA Gene Sequencing. Journal of Clinical Microbiology, v.44, n.10, p.3510-3516, 2006.

MOSALLANEJAD, B.; GHORBANPOOR, NAJAFABADI, M.; AVIZEH, R.; ABDOLLAHPOUR, G.R.; ABADI, K. A serological survey of Leptospiral infection of cats in Ahvaz, southwestern of Iran. International Journal of Veterinary Research, v.5, p.49-52, 2011.

MUSSO, D.; LA SCOLA, B. Laboratory diagnosis of leptospirosis: A challenge. Journal of Microbiology, Immunology and Infection, v.46, n.245-252, 2013.

MYLONAKIS, M.E.; BOURTZI-HATZOPOULOU, E.; KOUTINAS, A.F.; PETRIDOU, E.; SARIDOMICHELAKIS, M.N.; LEONTIDES, L.; SIOCHU, A. Leptospiral seroepidemiology in a feline hospital population in Greece. Veterinary Record, v.156, n.19, p.615-616, 2005.

ORTEGA-PACHECO, A.; GUZMAN-MARIN, E.; ACOSTA-VIANA, K.Y.; VADO-SOLIS, I.; JIMENEZ-DELGADILLO, B.; CARDENAS-MARRUFO, M.; PEREZ-OSORIO, C.; PUERTO-SOLIS, M.; JIMENEZ-COELLO, M. Serological survey of Leptospira interrogans, Toxoplasma gondii and Trypanosoma cruzi in free roaming domestic dogs and cats from a marginated rural area of Yucatan Mexico. Veterinary Medicine and Science, v.3, n.1, p.40-47, 2017.

PALANIAPPAN RU, CHANG YF, CHANG CF, PAN MJ, YANG CW, HARPENDING P, MCDONOUGH, S.P.; DUBOVI, E.; DIVERS, T.; QU, J.; ROE, B. Evaluation of lig-based conventional and real time PCR for the detection of pathogenic leptospires. Molecular and Cells Probes, v.19, p.111-117, 2005.

PARREIRA, I.M.; JAYME, V.S.; DE BUZIN, E.J.W.K.; TOMAZ, L.A.G.; DELFINO, D.A.A. Epidemiological features of infection through Leptospira spp. in domestic cats (Felis Catus) apparently healthy within the metropolitan area of Goiânia, Brazil. Enciclopédia Biosfera, v.6, n.9, p.1-5, 2010.

PICARDEAU, M. Diagnosis and epidemiology of leptospirosis. Médecine et maladies infectieuses, v.43, n.1, p.1-9, 2013.

PICARDEAU, M. Virulence of the zoonotic agent of leptospirosis: still terra incognita? Nature Reviews Microbiology, v.15, n.5, p. 297-307, 2017.

POLACHINI, C.O.; FUJIMORI, K. Canine and human leptospirosis, a possible conjunctival transmission in the Municipality of São Paulo, São Paulo State, Brazil. Revista Pan-Amazônica de Saúde, v.6, n.3, p.59-65, 2015.

PRANDOVSZKY, E.; GASKELL, E.; MARTIN, H.; DUBEY, J.P.; WEBSTER, J.P.; MCCONKEY, G.A.The Neurotropic Parasite Toxoplasma Gondii Increases Dopamine Metabolism. PLoS ONE, v.6, n.9, p.1-9, 2011.

RODRIGUEZ, J.; BLAIS, M-C.; LAPOINTE, C.; ARSENAULT, J.; CARIOTO, L.; HAREL, J. Serologic and Urinary PCR survey of leptospirosis in healthy cats and in cats with kidney disease. Journal of Veterinary Internal Medicine, v.28, n.2, p. 284–293, 2014.

ROJAS, P.; MONAHAN, A.M.; SCHULLER, S.; MILLER, I.S.; MARKEY, B.K.; NALLY, J.E. Detection and quantification of leptospires in urine of dogs: a maintenance host for the zoonotic disease leptospirosis. European Journal of Clinical Microbiology & Infectious Diseases, v.29, n.10, p.1305-1309, 2010.

SANTOS, J.P.; FERREIRA JÚNIOR, A.; MUNDIM, E.V.; SANTOS, M.P.; OLIVEIRA, P.R.; LIMA, A.M.C. Pesquisa de aglutininas anti-Leptospira em gatos errantes da cidade de Uberlândia – MG. Veterinária Notícias, v.12, n.2, p.122, 2006.

SARMENTO, A.M.C.; GUAZELLI, A.; BARRETO, L.F.G.; DA COSTA, V.M.; HOFFMANN, J.L.; LUCHEIS, S.B.; LANGONI, H.; PINHEIRO, S.R. Estudo da leptospirose em cães e gatos, da leishmaniose e da doença de Chagas em cães de aldeias indígenas guaranis em Parelheiros, Município de São Paulo-SP. Veterinária e Zootecnia, v.14, n.2, p.193-203, 2007.

SCHULLER, S.; FRANCEY, T.; HARTMANN, K.; HUGONNARD, M.; KOHN, B.; NALLY, J.E.; SYKES, J. European consensus statement on leptospirosis in dogs and cats. Journal of Small Animal Practice, v.56, n.3, p.159-179, 2015.

SILVA, F.J.; MATHIAS, L.; LOFFER, S.; BRIHUEGA, B.; SAMARTINO, L.; SANTOS, C.; SILVA, G.; ALARCON, M. Isolation of Leptospira spp. in Small Farm Populations in Nine States of Brazil. International Journal of Epidemiology, v.44, supl.1, p.i204, 2015.

SHOPHET, R. A serological survey of leptospirosis in cats. New Zealand Veterinary Journal, v.27, n.11, p.236, 245-246, 1979.

SHOPHET, R.; MARSHALL, R.B. An experimentally induced predator chain transmission of Leptospira ballum from mice to cats. British Veterinary Journal, v.136, n.3, p.265-270, 1980. 23.

SHROPSHIRE, S.B.; VEIR, J.K.; MORRIS, A.K.; LAPPIN, M.R. Evaluation of the Leptospira species microscopic agglutination test in experimentally vaccinated cats and Leptospira species seropositivity in aged azotemic client-owned cats. Journal of Feline Medicine and Surgery, v.18, n.10, p.768-772, 2016.

SONJA, O.; SONJA, R.; NATASA, E.; DANICA, B.; SLOBODANKA, V.; MIROSLAV, V. Seroprevalence of cat leptospirosis in Belgrade (Serbia). Acta veterinária, v.64, n.4, p.510-518, 2014.

SYKES, J.E.; HARTMANN, K.; LUNN, K.F.; MOORE, G.E.; STODDARD, R.A.; GOLDSTEIN, R.E. 2010 ACVIM Small animal consensus statement on leptospirosis: diagnosis, epidemiology, treatment, and prevention. Journal of Veterinary Internal Medicine, v.25, p.1-13, 2011.

TALEBKHAN GAROUSSI, M.; MEHRAVARAN, M.; ABDOLLAHPOUR, G.; KHOSHNEGAH, J. Seroprevalence of leptospiral infection in feline population in urban and dairy cattle herds in Mashhad, Iran. Veterinary Research Forum, v.6, n.4, p.301-304, 2015.

TORTEN, M.; SHENBERG, E.; VAN DER HOEDEN, J. The role of birds in the epidemiology of leptospirosis. Tropical and Geographical Medicine, v.17, p.353-358, 1965.

TRUONG, Q.L.; SEO, T.W.; YOON, B.I.; KIM, H.C.; HAN, J.H.; HAHN, T.W. Prevalence of swine viral and bacterial pathogens in rodents and stray cats captured around pig farms in Korea. The Journal of Veterinary Medical Science, v.75, n.12, p.1647-1650, 2013.

TUZIO H, EDWARDS D, ELSTON T, JARBOE L, KUDRAK S, RICHARDS J, RODAN I. Feline zoonoses guidelines from the American Association of Feline Practitioners. Journal of Feline Medicine and Surgery, v.7, p.243-274, 2005.

UHART, M.M.; RAGO, V.; MARULL, C.A.; FERREYRA, H-D-V.; PEREIRA, J.A. Exposure to selected pathogens in geoffroy’s cats and domestic carnivores from Central Argentina. Journal of Wildlife Diseases. v.48, n.4, p.899-909, 2012.

ULLMANN, L.S.; HOFFMANN, J.L.; DE MORAES, W.; CUBAS, Z.S.; DOS SANTOS, L.C.; DA SILVA, R.C.; MOREIRA, N.; GUIMARAES, A.M.S.; CAMOSSI, L.G.; LANGONI, H.; BIONDO, A.W. Serologic Survey For Leptospira spp. In Captive Neotropical Felids in Foz do Iguaçu, Paraná, Brazil. Journal of Zoo and Wildlife Medicine, v.43, n.2, p.223-228, 2012.

VAN DE MAELE, I.; CLAUS, A.; HAESEBROUCK, F.; DAMINET, S. Leptospirosis in dogs: a review with emphasis on clinical aspects. Veterinary Record, v.163, n.14, p. 409-413, 2008.

VASHI, N.A.; REDDY, P.; WAYNE, D.B.; SABIN, B. Bat-Associated Leptospirosis. Journal of General Internal Medicine, v.25, n.2, p.162-164, 2010.

WEIS, S.; RETTINGER, A.; BERGMANN, M.; LLEWELLYN, J.R.; PANTCHEV, N.; STRAUBINGER, R.K.; HARTMANN, K. Detection of Leptospira DNA in urine and presence of specific antibodies in outdoor cats in Germany. Journal of Feline Medicine and Surgery, v.19, n.4, p.470-476, 2017.


Texto completo: PDF

Apontamentos

  • Não há apontamentos.


 


 

 

Counters
Visitas