Crotalus durissus venom: biological effects and relevant applications
Resumo
Snakes have an important biological role in the ecological chain, as well as in scientific researches performed with the venoms produced by them, since the enzyme-protein fractions these substances possess have been studied as pharmacological tools for the discovery of new therapies. Snakes of the genus Crotalus have gained significant relevance in the scientific field, since the venom produced by these reptiles has been the target of researchers in a few decades, due to the composition and the effects that these substances can produce. In Brazil, a single species represents the genus, which is Crotalus durissus. This review demonstrates that even with the advancement in scientific research on the composition, role and application of the venom produced by the subspecies of Crotalus durissus snake, it is necessary to further study their fractions and their action potential, which also demonstrates the how rich are these active components in different fields of biomedicine.
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Referências
BARROS, L.C; SOARES, A.M.; COSTA, F.L.; RODRIGUES, V.M.; FULY, A.L.; GIGLIO, J.R.; GALLACCI, M.; THOMAZINI-SANTOS, I. A.; BARRAVIEIRA, S.R.C.S.; FERREIRA JUNIOR, R.S. Biochemical and biological evaluation of gyroxin isolated from Crotalus durissus terrificus venom. The Journal of Venomous Animals and Toxins including Tropical Diseases, v. 17, n. 1, p. 23–33, 2011.
BEGHINI, D.G.; TOYAMA, M.H.; HYSLOP, S.; SODEK, L.; NOVELLO, J.C.; MARANGONI, S. Enzymatic characterization of a novel phospholipase A2 from Crotalus durissus cascavella rattlesnake (Maracambóia) venom. Journal of Protein Chemistry, v. 19, n. 8, p. 679–684, 2000.
BOLDRINI-FRANÇA, J.; CORRÊA-NETTO, C.; SILVA, M.M.S.; RODRIGUES, R.S.; DE LA TORRE, P.;PÉREZ, A.; SOARES, A.M.; ZINGALI, R.B.; NOGUEIRA, R.A.; RODRIGUES, V.M.; SANZ, L.; CALVETE, J.J. Snake venomics and antivenomics of Crotalus durissus subspecies from Brazil: assessment of geographic variation and its implication on snakebite management. Journal of Proteomics, v. 73, n. 9, p. 1758–1776, 2011.
BON, C.;CHANGEUX, J.P.; JENG, T.W.; FRAENKEL-CONRAT, H. Postsynaptic effects of crotoxin and of its isolated subunits. European Journal of Biochemistry, v. 99, n. 3, p. 471–481, 1979.
BON, C. Snake venom and pharmacopoeia. In: BAUCHOT, R. (Ed.) Snakes: A Natural History. New York: Sterling Publishing Company, 2006. p. 194-209.
BREITHAUPT, H.; RÜBSAMEN, K.; HABERMANN, E. Biochemistry and pharmacology of the crotoxin complex. Biochemical analysis of crotapotin and the basic Crotalus phospholipase A. European Journal of Biochemistry / FEBS, v. 49, n. 2, p. 333–345, 1974.
CÂMARA, P.; ESQUISATTO, L.; CAMARGO, E.; RIBELA, M.; TOYAMA, M.; MARANGONI, S.; DE NUCCI, G.; ANTUNES, E. Inflammatory edema induced by phospholipases A2 isolated from Crotalus durissus sp. in the rat dorsal skin: A role for mast cells and sensory c-fibers. Toxicon, v. 41, n. 1, p. 823–829, 2003.
CAMILLO, M. Contribuição ao estudo das giroxinas (enzimas semelhantes à trombina) dos venenos das serpentes brasileiras Lachesis muta muta e Crotalus durissus terrificus, 1998. 75f. Tese (Doutorado em Ciências) – Instituto de Pesquisas Energéticas e Nucleares, São Paulo, SP, 1998.
DIZ FILHO, E.B.S.; MARANGONI, S.; TOYAMA, D.O.; FAGUNDES, F.H.R.; OLIVEIRA, S.C.B.; FONSECA, F. V.; CALGAROTTO, A.K.; JOAZEIRO, P. P.; TOYAMA, M. H. Enzymatic and structural characterization of new PLA2 isoform isolated from white venom of Crotalus durissus ruruima. Toxicon, v. 53, n. 1, p.104–114, 2009.
EVANGELISTA, J.S.A.M.; MARTINS, A.M.C.; NASCIMENTO, N. R.F.; SOUSA, C.M.; ALVES, R.S.; TOYAMA, D.O.; TOYAMA, M.H.; EVANGELISTA, J.J.F.; MENEZES, D.M.; MANASSÉS, C.F.; MORAES, M.E.A.; MONTEIRO, H.A.S. Renal and vascular effects of the natriuretic peptide isolated from Crotalus durissus cascavella venom. Toxicon, v. 52, n. 7, p. 737–744, 2008.
FERRARO, G.C.; MORAES, J.R.E.; SHIMANO, A.C.; PEREIRA, G.T. ; MORAES, F. R.; BUENO DE CAMARGO, M.H. Effect of snake venom derived fbrin glue on the tendon healing in dogs. Clinical and biomechanical study. Journal of Venomous Animals and Toxins including Tropical Diseases, v. 11, n. 3, p. 261–74, 2005.
FONSECA, F.V.; ANTUNES, E.; MORGANTI, R.P.; MONTEIRO, H. S.A.; MARTINS, A.M.C.; TOYAMA, D.O.; MARANGONI, S. Characterization of a new platelet aggregating factor from crotoxin Crotalus durissus cascavella venom. The Protein Journal, v. 25, n. 3, p. 183–192, 2006.
GIORGI, R.; BERNARDI, M.; CURY, Y. Analgesic effect evoked by low molecular weight substances extracted from Crotalus durissus terrificus venom. Toxicon, v. 31, n. 1, p. 1257–1265, 1993.
GOPALAKRISHNAKONE, P.; DEMPSTER, D.W.; HAWGOOD, B. J.;ELDER, H.Y. Cellular and mitochondrial changes induced in the structure of murine skeletal muscle by crotoxin, a neurotoxic phospholipase A2 complex. Toxicon, v. 22, n. 1, p. 85–98, 1984.
GUTIERREZ, V.; KONNO, K.; CHACUR, M.; SAMPAIO, S.; PICOLO, G.; BRIGATTE, P.; ZAMBELLI, V.; CURY, Y. Crotalphine induces potent anti-nociception in neuropathic pain by acting at peripheral opioid receptors. European Journal of Pharmacology, v. 594, n. 1, p. 84–92, 2008.
HENDON, R.A.; FRAENKEL-CONRAT, H. Biological role of the two components of CrTX. Proceedings of the National Academy of Sciences, v. 68, n. 7, p. 1560–1563, 1971.
JANDROT-PERRUS, M.; LAGRUE, A.H; OKUMA, M.; BON, C. Adhesion and activation of human platelets induced by convulxin involves glycoprotein VI and integrin alpha2beta1. The Journal of Biological Chemistry, v. 272, n. 43, p. 27035–27041, 1997.
KANAJI, S.; KANAJI, T.; FURIHATA, K.; KATO, K.; WARE, J.L; KUNICLI, T.J. Convulxin binds to native, human glycoprotein IBα. The Journal of Biological Chemistry, v. 278, n. 41, p. 39452–39460, 2003.
KONNO, K.; PICOLO, G.; GUTIERREZ, V.; BRIGATTE, P.; ZAMBELLI, V.; CAMARGO, C.; CURY, Y. Crotalphine, a novel potent analgesic peptide from the venom of the South American rattlesnake Crotalus durissus terrificus. Peptides, v. 29, n. 1, p. 1293–1304, 1998.
LEDUC, M.; BON, C. Cloning of subunits of convulxin, a collagen-like platelet- aggregating protein from Crotalus durissus terrificus venom. Biochemical Journal, v. 333, n. 1, p. 389–393, 1998.
LIMA, D.; ABREU, P.; FREITAS, C.; SANTOS, D.; BORGES, R.; SANTOS, T.; CABRAL, L.; RODRIGUES, C.; CASTRO H. Snake Venom: Any Clue for Antibiotics and CAM? Evidence-based Complementary and Alternative Medicine, v. 2, n. 1, p. 39–47, 2005.
LOMONTE, B.; ANGULO, Y.; CALDERÓN, L. An overview of lysine-49 phospholipase A2 myotoxin from crotalid snake venoms and their structural determinants of myotoxic action. Toxicon, v. 42, n. 1, p. 885–901, 2003.
MARTINS, A.M.C.; LIMA, A.A.M.; TOYAMA, M.H.; MARANGONI, S.; FONTELES, M.C.; MONTEIRO, H.A.S. Renal effects of supernatant from macrophages activated by Crotalus durissus cascavella venom: the role of phospholipase A2 and cyclooxygenase. Pharmacology & Toxicology, v. 92, n. 1, p. 14–20, 2003.
MATSUBARA, M.H. Efeitos do veneno de Crotalus durissus terrificus, da crotoxina e de suas subunidades fosfolipase A2 e crotapotina em monocamadas de células endoteliais em cultura, 2009. 106f. Dissertação (Mestrado em Biotecnologia) – Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, SP, 2009.
MATSUI, T.; FUJIMURA, Y.; TITANI, K. Snake venom proteases afecting hemostasis and thrombosis. Biochim Biophys Acta, v. 1477, n.1-2, p. 146-156, 2000.
MORAES, J.R.E.; CORREA, P.H.A.; CAMPLESI, A.C.; MORAES, F.R. Experimental use of fbrin glue derived from snake venom in non-pregnant canine uterus. Journal Venom Animals Toxins including Tropical Diseases, v.10, n.2, p.133–143, 2004.
NOGUEIRA-NETO, F.S.; AMORIM, R.L.; BRIGATTE, P.; PICOLO, G.; FERREIRA, J.R.W.A.; GUTIERREZ, V.P.; CONCEIÇÃO, I. M.; DELLA-CASA, M.S.; TAKAHIRA, R.K.B.; NICOLETTI, J.L.M.; CURY, Y. The analgesic effect of crotoxin on neuropathic pain is mediated by central muscarinic receptors and 5-lipoxygenase-derived mediators. Pharmacology, Biochemistry and Behavior, v. 91, n. 2, p. 252–260, 2008.
OLIVEIRA, D.G.; TOYAMA, M.H.; MARTINS, A.M.; HAVT, A.; NOBRE, A.C.L.; MARANGONI, S.; CÂMARA, P.R.; ANTUNES, E.; DE NUCCI, G.; BELIAM, L.O.S.; FONTELES, M.C.; MONTEIRO, H.S A. Structural and biological characterization of a crotapotin isoform isolated from Crotalus durissus cascavella venom. Toxicon, v. 42, n. 1, p. 53–62, 2003.
PASSERO, L.F.; TOMOKANE, T.; CORBETT, C.; LAURENTI, M. D.; TOYAMA, M. Comparative studies of the anti-leishmanial activity of three Crotalus durissus sp. venoms. Parasitology Research, p.1365–1371, 2007.
PEREAÑEZ, J.Á.; NÚÑEZ, V.; HUANCAHUIRE-VEJA, S.; MARANGONI, S.; PONCE-SOTO, L.A. Biochemical and biological characterization of a PLAR (2R) from crotoxin complex of Crotalus durissus cumanensis. Toxicon, v.53, n.5, p.534–542, 2009.
PINHO, F.M.O.; PEREIRA, I.D. Ofidismo. Revista da Associação Médica Brasileira, v. 47, n. 1, p. 24–29, 2001.
POLGÁR, J.; CLEMETSON, J.M.; KEHREL, B.E.; WIEDEMANN, M.; MAGNENAT, E. M.; WELLS, T.N.; CLEMETSON, H. J. Platelet activation and signal trans by convulxin, a C-type lectin from Crotalus durissus terrificus (tropical rattlesnake) venom via the p62/GPVI collagen receptor. The Journal of Biological Chemistry, v. 272, n. 21, p. 13576–13583, 1997.
PRADO-FRANCESCHI, J. On the pharmacology of convulxin and giroxin. Memórias do Instituto Butantan, v. 52, p. 1, p. 25–26, 1990.
RANGEL-SANTOS, A.; DOS SANTOS, E.C.; LOPES-FERREIRA, M.; LIMA C.; CARDOSO, D.F.; MOTA, I.A. Comparative study of biological activities of crotoxin and CB fraction of venoms from Crotalus durissus terrificus, Crotalus durissus cascavella and Crotalus durissus collilineatus. Toxicon, v. 43, n. 7, p. 801–810, 2004.
RAW, I.; ROCHA, M.C.; ESTEVES, M.I.; KAMIGUTI, A.S. Isolation and characterization of a thrombin-like enzyme from the venom of Crotalus durissus terrificus. Brazilian Journal of Medical and Biological Research, v. 19, n. 3, p. 333–338, 1986.
SAMPAIO, S.C.; RANGEL-SANTOS, A.C.; PERES, C.M.; CURI, Y. Inhibitory effect of phospholipase A2 isloated from Crotalus durissus terrificus venom on macrophage function. Toxicon, v. 45, n. 5, p. 671–676, 2005.
SAMY, R.P.; PACHIAPPAN, A.; GOPALAKRISHNAKONE, P.; THWIN, M.M.; HIAN, Y.E.; CHOW, L.; BOW, H.; WENG, J.T. In vitro antimicrobial activity of natural toxins and animal venoms tested against Burkholderia pseudomallei. BMC Infectious Diseases, v. 6, n. 1, p. 100–115, 2006.
SAMY, R.P.; GOPALAKRISHNAKONE, P.; THWIN, M.; CHOW, T. K.V.; BOW, H.; YAP, E.; THONG, T. Antibacterial activity of snake, scorpion and bee venoms: a comparison with purified venom phospholipase A2 enzymes. Journal of Applied Microbiology, v. 102, n. 1, p. 650–659, 2007.
SANO-MARTINS, I.S.; TOMY, S.C.; CAMPOLINA, D.; DIAS, M.B.; DE CASTRO, S.C.B.; SOUSA-E-SILVA, M.C.C.; AMARAL, C.F. S.; REZENDE, M.A.; KAMIGUTI, A.S.; WARRELL, D.A.; THEAKSTON, R.D.G. Coagulopathy following lethal and non-lethal envenoming of humans by the South American rattlesnake in Brazil. The Quarterly Journal of Medicine, v. 94, n. 10, p. 551–559, 2001.
SANTOS, E. Anfíbios e Répteis. 3.ed. Belo Horizonte: Itatiaia, 1995, 263p.
SERRANO, S.M.; MAROUN, R.C. Snake venom serine proteinases: sequence homology vs. substrate specificity, a paradox to be solved. Toxicon, v. 45, n. 8, p. 1115–1132, 2005.
SILVA, M. G. C. Câncer em Fortaleza: 1978-1980. Fortaleza, Instituto e Registro de câncer do Ceará, 1982.
SLOTTA, K.H.; FRAENKEL-CONRAT, H. Estudos químicos sobre os venenos ofídicos. Purificação e cristalização do veneno da cobra cascavel. Memórias do Instituto Butantan, v. 12, n. 1, p. 505-512, 1938.
SOARES, A.M.; MANCIN, A.; CECCHINI, A.; ARANTES, E.; FRANÇA, S.C.; GUTIÉRREZ, J.M.; GIGLIO, J. Effects of chemical modifications of crotoxin B, the phospholipase A2 subunit of crotoxin from Crotalus durissus terrificus snake venom, on its enzymatic and pharmacological activities. The International Journal of Biochemistry & Cell Biology, v. 33, n. 1, p. 877–888, 2001.
TAMIETI, B.P.; DAMATTA, R.A.; COGO, J.C.; DA SILVA, N.S.; MITTMANN, J.P.S.C. Cytoskeleton, endoplasmic reticulum and nucleus alterations in cho-k1 cell line after Crotalus durissus terrificus (south american rattlesnake) venom treatment. Journal of Venomous Animals and Toxins Including Tropical Diseases, v.13, p. 56–58, 2007.
TOYAMA, M.H.; CARNEIRO, E.M.; MARANGONI, S.; AMARAL, M.E.C.;VELLOSO, L.A.; BOSCHERO, A.C. Isolation and characterization of a Convulxin like protein from Crotalus durisssus collilineatus venom. Journal of Protein Chemistry, v. 20, n. 7, p. 585–591, 2001.
TOYAMA, M.; OLIVEIRA, D.; BERIAM, L.; NOVELLO, J.; RODRIGUES-SIMIONI, L.; MARANGONI, S. Structural, enzymatic and biological properties of new PLA2 isoform from Crotalus durissus terrificus venom. Toxicon, v. 41, n. 1, p. 1033–1038, 2003.
TOYAMA, M.H.; TOYAMA, D.D.O.; PASSERO, L.F.D.; LAURENTI, M.D.; CORBETT, C.E.; TOMOKANE, T.Y.; FONSECA, F.V. ; ANTUNES, E.;JOAZEIRO, P.P.;BERIAM, L.O.S.;MARTINS, M. A. C; MONTEIRO, H.S.A.; FONTELES, M.C. Isolation of a new L-amino acid oxidase from Crotalus durissus cascavella venom. Toxicon, v. 47, n. 1, p. 47–57, 2006.
YAN, C.; LIANG, Z.; GU, Z.; YANG, Y.; REID, P.; QIN, Z. Contributions of autophagic and apoptotic mechanisms to CrTX-induced death of K562 cells. Toxicon, v. 47, n. 1, p. 521–530, 2006.
YAN, C.; YANG, Y.; QIN, Z.; GU, Z.; REID, P; LIANG, Z. Autophagy is involved in cytotoxic effects of crotoxin in human breast cancer cell line MCF-7 cells. Acta Pharmacologica Sinica, v. 28, n. 4, p.540–548, 2007.
ZHANG, H.L.; HAN, R.; CHEN, Z.X.; CHEN, B.W.; GU, Z.L.; REID, P.F. Opiate and acetylcholine-independent analgesic actions of crotoxin isolated from Crotalus durissus terrificus venom. Toxicon, v. 48, n. 2, p. 175–182, 2006.
ZHU, Q.; WU, D.C.; ZHOU, X.P.; GONG, S.; CHENG, B.C.; QIN, Z.H. Inhibitory effect of crotoxin on the pain-evoked discharge of neurons in thalamic parafascicular nucleus in rats. Toxicon, v. 51, n. 1, p. 102–111, 2008.
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