Xenotransplante de tecidos ovários em animais: limitações, técnicas e inovações. Uma revisão

Muriel Magda Lustosa Pimentel, Fernanda Araújo dos Santos, Gleidson Benevides de Oliveira, Michelly Fernandes de Macedo, Marcelo Barbosa Bezerra

Resumo


Xenotransplante consiste em transplantar órgãos, tecidos e/ou células de animais, geneticamente modificados ou não, entre espécies diferentes. O xenotransplante ovariano é utilizado como método de coleta e maturação dos folículos e seus oócitos, e para tanto é necessário ainda aprimoramento de algumas técnicas. Este artigo de revisão tem como objetivo, abordar aspectos fisiológicos foliculares e registrar o aperfeiçoamento da técnica e de que forma os pesquisadores vêm conduzindo seus estudos nos últimos anos em xenotransplante ovariano animal.


Palavras-chave


folículos; oócitos; ovário; transplante

Referências


AERTS, J.M.; MARTINEZ-MADRID, B.; LEROY, J.L.; VAN AELST, S.; BOLS, P.E. Xenotransplantation by injection of a suspension of isolated preantral ovarian follicles and stroma cells under the kidney capsule of nude mice. Fertility and sterility, v. 94, n. 2, p. 708-714, 2010.

AUBARD, Y. Ovarian tissue xenografting. European Journal of Obstetrics e Gynecology and Reproductive Biology, v. 108, p.14-18, 2003.

BEZERRA, M.B. Folículos ovarianos pré-antrais bovinos: cultivo in vitro e xenotransplante. 2010. 63f. Tese (Doutorado em Medicina Veterinária) – Universidade Estadual Paulista, Faculdade de Ciências Agrárias e Veterinárias, Jaboticabal, SP.

BOSCH, P.; HERNANDEZ-FONSECA, H.J.; MILLER D.M.; WININGER, J.D.; MASSEY, J.B.; LAMB, S.V.; BRACKETT, B.G. Development of antral follicles in cryopreserved cat ovarian tissue transplanted to immunodeficient mice. Theriogenology, v. 61, n. 2, p. 581-594, 2004.

CASSANDRA, L.K. Forkhead Box N1; Foxn1, 15 jan. 2014. Capturado em 15 jan. 2014. Online.

CANDY, C.J.; WOOD, M.J.; WHITTINGHAM, D.G. Ovary and ovulation: Follicular development in cryopreserved marmoset ovarian tissue after transplantation. Human Reproduction, v. 10, n. 9, p. 2334-2338, 1995.

CLEARY, M.; PARIS, M.C.J.; SHAW, J.; JENKIN, G.; TROUNSON, A. Effect of ovariectomy and graft position on cryopreserved common wombat (Vombatus ursinus) ovarian tissue following xenografting to nude mice. Reproduction, Fertility and Development, v. 15, n. 6, p. 333-342, 2003. doi: 10.1071/RD03063.

CUPERSCHMID, E.M.; CAMPOS, T.P.R. Os curiosos xenoimplantes glandulares do doutor Voronoff. História, Ciências e Saúde, v.14, n.3, p.737-760, 2007.

DEMIRCI, B.; LORNAGE, J.; SALLE, B.; POIREL, M.T.; GUERIN J.F.; FRANCK, M. The cryopreservation of ovarian tissue: uses and indications in veterinary medicine. Theriogenology, v. 60, p. 999-1010, 2003.

DOS SANTOS, F.B. Camundongos mutantes mais utilizados. Capturado em: 28 ago. 2014. Online.

EPPIG, J.J.; SCHROEDER, A.C. Capacity of mouse oocytes from preantral follicles to undergo embryogenesis and development to live young after growth, maturation, and fertilization in vitro. Biology of Reproduction, v.41, n.2, p.268-276, 1989.

GOSDEN, R.G.; BOULTON, M.I.; GRANT, K.; WEBB, R. Follicular development from ovarian xenografts in SCID mice. Journal of reproduction and fertility, v. 101, n. 3, p. 619-623, 1994.

GUNASENA, K.T.; LAKEY, J.R.T.; VILLINES, P.M.; BUSH, M.; RAATH, C.; CRITSER, E.S.; CRITSER, J.K. Antral follicles develop in xenografted cryopreserved african elephant (Loxodonta africana) ovarian tissue. Animal reproduction science, v. 53, n. 1, p. 265-275, 1998.

HANCOCK, W.W. Delayed xenograft rejection. World journal of surgery, v. 21, n. 9, p. 917-923, 1997.

HERNANDEZ-FONSECA H.J.; BOSCH, P.; WININGER J.D.; MASSEY J.B.; CHO H.; BRACKETT, B.G. Recovery of oocytes from bovine ovarian tissue transplanted to NOD SCID mice. Fertil Steril; 76(Suppl 1):S56, 2001.

HERNANDEZ-FONSECA H.J.; BOSCH, P.; MILLER, D.M.; WININGER, J.D.; MASSEY, J.B.; BRACKETT, B.G. Time course of follicular development after bovine ovarian tissue transplantation in male non-obese diabetic severe combined immunodeficient mice. Fertility and sterility, v. 83, n. 4, p. 1180-1187, 2005.

HIRSHFIELD, A.N. Size-frequency analysis of atresia in cicling rats. Biology of Reproduction, v.38, n.5, p.1181-1188, 1988.

KANEKO, H.; KIKUCHI, K.; NOGUCHI, J.; HOSOE, M.; AKITA T. Maturation and fertilization of porcine oocytes from primordial follicles by a combination of xenografting and in vitro culture. Biology of reproduction, v. 69, n. 5, p. 1488-1493, 2003.

KANEKO, H.; KIKUCHI, K.; NOGUCHI, J.; OZAWA, M.; OHNUMA, K.; MAEDOMARI, N.; KASHIWAZAKI, N. Effects of gonadotrophin treatments on meiotic and developmental competence of oocytes in porcine primordial follicles following xenografting to nude mice. Reproduction, v. 131, n. 2, p. 279-288, 2006.

KANEKO, H.; NAKAI, M.; TANIHARA, F.; NOGUCHI, J.; KIKUCHI, K. Improved developmental ability of porcine oocytes grown in nude mice after fusion with cytoplasmic fragments prepared by centrifugation: A model for utilization of primordial oocytes. Theriogenology, v. 80, n. 8, p. 887-892, 2013.

KIKUCHI, K.; KANEKO, H.; NAKAI, M.; NOGUCHI, J.; OZAWA, M.; OHNUMA, K.; KASHIWAZAKI, N. In vitro and in vivo developmental ability of oocytes derived from porcine primordial follicles xenografted into nude mice. The Journal of reproduction and development, v. 52, n. 1, p. 51, 2006.

MACEDO, M.F.; BEZERRA, M.B.; VICENTE, W.R.R. Transplante ovariano: aplicações na reprodução de animais domésticos, silvestres e humanos. Acta Veterinaria Brasilica, v. 5, n. 1, p. 1-7, 2011.

MARCHAL, R.; VIGNERON, C.; PERREAU, C.; BALI-PAPP, A.; MERMILLOD, P. Effect of follicular size on meiotic and developmental competence of porcine oocytes. Theriogenology, v. 57, n. 5, p. 1523-1532, 2002.

MATTISKE, D.; SHAW, G.; SHAW, J.M. Influence of donor age on development of gonadal tissue from pouch young of the tammar wallaby, Macropus eugenii, after cryopreservation and xenografting into mice. Reproduction, v. 123, n. 1, p. 143-153, 2002.

MOTLIK, J.; CROZET, N.; FULKA, J. Meiotic competence in vitro of pig oocytes isolated from early antral follicles. Journal of reproduction and fertility, v. 72, n. 2, p. 323-328, 1984.

PIERSON, R.N.; DORLING, A.; AYARES, D.; REES, M.A.; SEEBACH, J.D.; FISHMAN, J.A.; COOPER, D.K. Current status of xenotransplantation and prospects for clinical application. Xenotransplantation, v. 16, n. 5, p. 263-280, 2009.

ROBSON, S.C. Factors in xenograft rejection. Annals of the New York Academy of Sciences, v. 875, n. 1, p. 261-276, 1999.

SENBON, S.; OTA, A.; TACHIBANA, M.; MIYANO, T. Bovine oocytes in secondary follicles grow and acquire meiotic competence in severe combined immunodeficient mice. Zygote, v.11, p.139-149, 2003.

SENBON, S.; ISHII, K.; FUKUMI, Y.; MIYANO, T. Fertilization and development of bovine oocytes grown in female SCID mice. Zygote, v.13, p.309-315, 2005.

THIBAULT, C.; LEVASSEUR, M.C. La Reproduction Chez Les Mammifères Et L’Homme. 2ed. Paris: Ellipses, 2001. cap.15. p.316- 347.

VALLOTTON, M.; WEIBEL, E.R. Medical-ethical principles on xenotransplantation. Swiss Medical Weekly, v. 131, n. 25-26, p. 388-394, 2001.

WIEDEMANN, C.; HRIBAL, R.; RINGLEB, J.; BERTELSEN, M.F.; RASMUSEN, K.; ANDERSEN, C.Y.; JEWGENOW, K. Preservation of Primordial Follicles from Lions by Slow Freezing and Xenotransplantation of Ovarian Cortex into an Immunodeficient Mouse. Reproduction in Domestic Animals, v. 47, n. s6, p. 300-304, 2012.


Texto completo: PDF

Apontamentos

  • Não há apontamentos.


 


 

 

Counters
Visitas